Revista da Sociedade Brasileira de Medicina Tropical (Jan 2019)

Good response to pentamidine isethionate in a case of Mucosal Leishmaniasis caused by Leishmania (Viannia) braziliensis that was difficult to treat: Case Report

  • Benivaldo Ramos Ferreira Terceiro,
  • Tania Salgado de Souza Torraca,
  • Frederico Pereira Bom Braga,
  • Ana Cristina da Costa Martins,
  • Lucia Regina Brahim,
  • Mauricio Naoto Saheki,
  • Luciana de Freitas Campos Miranda,
  • Armando de Oliveira Schubach,
  • Cláudia Maria Valete-Rosalino

DOI
https://doi.org/10.1590/0037-8682-0236-2018
Journal volume & issue
Vol. 52, no. 0

Abstract

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Abstract In Brazil, meglumine antimoniate is the first drug of choice for mucosal leishmaniasis treatment followed by amphotericin B and pentamidine isethionate. We report the case of a patient with severe mucosal lesions caused by Leishmania (Viannia) braziliensis that were difficult to treat. Over a 14-year period, the patient showed low adherence and three treatment attempts with meglumine antimoniate failed. Additionally, there was an unsatisfactory response to liposomal amphotericin B and nephrotoxicity when using amphotericin B deoxycholate that persisted after new treatment attempt with liposomal amphotericin B. Finally, healing was achieved with pentamidine isethionate and maintained during nine months of monitoring.

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