Frontiers in Neuroscience (Mar 2023)
Neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human, a pilot study
- Dongrong Lai,
- Dongrong Lai,
- Dongrong Lai,
- Zijun Wan,
- Zijun Wan,
- Zijun Wan,
- Jiafan Lin,
- Jiafan Lin,
- Jiafan Lin,
- Li Pan,
- Li Pan,
- Li Pan,
- Feixiao Ren,
- Feixiao Ren,
- Junming Zhu,
- Junming Zhu,
- Jianmin Zhang,
- Jianmin Zhang,
- Yueming Wang,
- Yueming Wang,
- Yueming Wang,
- Yaoyao Hao,
- Yaoyao Hao,
- Yaoyao Hao,
- Kedi Xu,
- Kedi Xu,
- Kedi Xu,
- Kedi Xu
Affiliations
- Dongrong Lai
- Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China
- Dongrong Lai
- Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China
- Dongrong Lai
- Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China
- Zijun Wan
- Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China
- Zijun Wan
- Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China
- Zijun Wan
- Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China
- Jiafan Lin
- Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China
- Jiafan Lin
- Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China
- Jiafan Lin
- Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China
- Li Pan
- Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China
- Li Pan
- Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China
- Li Pan
- Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China
- Feixiao Ren
- Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China
- Feixiao Ren
- College of Computer Science and Technology, Zhejiang University, Hangzhou, China
- Junming Zhu
- Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
- Junming Zhu
- MOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, China
- Jianmin Zhang
- Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
- Jianmin Zhang
- MOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, China
- Yueming Wang
- Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China
- Yueming Wang
- College of Computer Science and Technology, Zhejiang University, Hangzhou, China
- Yueming Wang
- MOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, China
- Yaoyao Hao
- Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China
- Yaoyao Hao
- College of Computer Science and Technology, Zhejiang University, Hangzhou, China
- Yaoyao Hao
- MOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, China
- Kedi Xu
- Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China
- Kedi Xu
- Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China
- Kedi Xu
- Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China
- Kedi Xu
- MOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, China
- DOI
- https://doi.org/10.3389/fnins.2023.1133928
- Journal volume & issue
-
Vol. 17
Abstract
IntroductionHow the human brain coordinates bimanual movements is not well-established.MethodsHere, we recorded neural signals from a paralyzed individual’s left motor cortex during both unimanual and bimanual motor imagery tasks and quantified the representational interaction between arms by analyzing the tuning parameters of each neuron.ResultsWe found a similar proportion of neurons preferring each arm during unimanual movements, however, when switching to bimanual movements, the proportion of contralateral preference increased to 71.8%, indicating contralateral lateralization. We also observed a decorrelation process for each arm’s representation across the unimanual and bimanual tasks. We further confined that these changes in bilateral relationships are mainly caused by the alteration of tuning parameters, such as the increased bilateral preferred direction (PD) shifts and the significant suppression in bilateral modulation depths (MDs), especially the ipsilateral side.DiscussionThese results contribute to the knowledge of bimanual coordination and thus the design of cutting-edge bimanual brain-computer interfaces.
Keywords
- motor imagery
- brain-computer interface (BCI)
- primary motor cortex (M1)
- bimanual arm movement
- neuronal representation
