Nature Communications (Jun 2021)

Post-myocardial infarction heart failure dysregulates the bone vascular niche

  • Jedrzej Hoffmann,
  • Guillermo Luxán,
  • Wesley Tyler Abplanalp,
  • Simone-Franziska Glaser,
  • Tina Rasper,
  • Ariane Fischer,
  • Marion Muhly-Reinholz,
  • Michael Potente,
  • Birgit Assmus,
  • David John,
  • Andreas Michael Zeiher,
  • Stefanie Dimmeler

DOI
https://doi.org/10.1038/s41467-021-24045-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Hematopoiesis influences the progression of cardiovascular disease, yet the influence of cardiovascular disease on the bone vasculature is unknown. Hoffmann, Luxán, Abplanalp et al. describe the response of the bone cell composition to myocardial infarction and provide a rationale for using anti-inflammatory therapies to prevent the deterioration of the bone vascular niche