Nature Communications (Nov 2017)
GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk
- Nicola Pirastu,
- Peter K. Joshi,
- Paul S. de Vries,
- Marilyn C. Cornelis,
- Paul M. McKeigue,
- NaNa Keum,
- Nora Franceschini,
- Marco Colombo,
- Edward L. Giovannucci,
- Athina Spiliopoulou,
- Lude Franke,
- Kari E. North,
- Peter Kraft,
- Alanna C. Morrison,
- Tõnu Esko,
- James F. Wilson
Affiliations
- Nicola Pirastu
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Peter K. Joshi
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Paul S. de Vries
- Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Marilyn C. Cornelis
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Paul M. McKeigue
- Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- NaNa Keum
- Department of Food Science and Biotechnology, Dongguk University
- Nora Franceschini
- Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina
- Marco Colombo
- Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Edward L. Giovannucci
- Department of Nutrition, Harvard T. H. Chan School of Public Health
- Athina Spiliopoulou
- Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Lude Franke
- Department of Genetics, University Medical Center
- Kari E. North
- Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina
- Peter Kraft
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health
- Alanna C. Morrison
- Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Tõnu Esko
- Estonian Genome Center, University of Tartu
- James F. Wilson
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-017-01490-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Male pattern baldness (MBP) is a complex trait that has genetic associations. Here, Pirastu and colleagues perform a genome-wide association study to show 71 susceptibility loci associated with MBP — 30 of which are novel — and that these loci can explain 38% of heritability.
