Multiple biological functions of transcription factor 21 in the development of various cancers

Abstract

Xiaodi Jiang,1 Zhi Yang2 1Department of Infectious Disease, The Shengjing Hospital of China Medical University, Shenyang, China; 2Department of Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China Abstract: Transcription factor 21 (TCF21) is a basic helix–loop–helix transcription factor that binds to DNA and regulates cell differentiation and cell fate specification through mesenchymal–epithelial transition during development. The TCF21 gene is epigenetically inactivated in many types of human cancers and exerts a wide variety of functions, including the regulation of epithelial–mesenchymal transition, invasion, metastasis, cell cycle, and autophagy. This review focuses on research progress in relation to the roles of TCF21 in tumor development. We systematically consider multiple pathological functions of TCF21 in various cancers, revealing the molecular bases of its diverse biological roles and providing new directions for future research. Keywords: TCF21, cancer, DNA methylation, EMT, invasion, metastasis, cell cycle

Keywords

• TCF21
• Cancer
• DNA methylation
• EMT
• Invasion
• Metastasis
• Cell cycle