International Journal of Molecular Sciences (Oct 2020)
Offensive Behavior, Striatal Glutamate Metabolites, and Limbic–Hypothalamic–Pituitary–Adrenal Responses to Stress in Chronic Anxiety
- Enrico Ullmann,
- George Chrousos,
- Seth W. Perry,
- Ma-Li Wong,
- Julio Licinio,
- Stefan R. Bornstein,
- Olga Tseilikman,
- Maria Komelkova,
- Maxim S. Lapshin,
- Maryia Vasilyeva,
- Evgenii Zavjalov,
- Oleg Shevelev,
- Nikita Khotskin,
- Galina Koncevaya,
- Anna S. Khotskina,
- Mikhail Moshkin,
- Olga Cherkasova,
- Alexey Sarapultsev,
- Roman Ibragimov,
- Igor Kritsky,
- Jörg M. Fegert,
- Vadim Tseilikman,
- Rachel Yehuda
Affiliations
- Enrico Ullmann
- Department of Pediatric Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, 04107 Leipzig, Germany
- George Chrousos
- School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia
- Seth W. Perry
- College of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA
- Ma-Li Wong
- College of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA
- Julio Licinio
- College of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA
- Stefan R. Bornstein
- Department of Medicine, Technical University of Dresden, 01309 Dresden, Germany
- Olga Tseilikman
- School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia
- Maria Komelkova
- School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia
- Maxim S. Lapshin
- School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia
- Maryia Vasilyeva
- School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia
- Evgenii Zavjalov
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia
- Oleg Shevelev
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia
- Nikita Khotskin
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia
- Galina Koncevaya
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia
- Anna S. Khotskina
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia
- Mikhail Moshkin
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia
- Olga Cherkasova
- Biophysics Laboratory, Institute of Laser Physics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia
- Alexey Sarapultsev
- Institute of Natural Sciences and Mathematics, Ural Federal University named after the first President of Russia, 620026 Ekaterinburg, Russia
- Roman Ibragimov
- Institute of Natural Sciences and Mathematics, Ural Federal University named after the first President of Russia, 620026 Ekaterinburg, Russia
- Igor Kritsky
- Institute of Natural Sciences and Mathematics, Ural Federal University named after the first President of Russia, 620026 Ekaterinburg, Russia
- Jörg M. Fegert
- Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Ulm, 89075 Ulm, Germany
- Vadim Tseilikman
- School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia
- Rachel Yehuda
- Traumatic Stress Studies Division, ICAHN School of Medicine at Mount Sinai, New York, NY 10029-6574, USA
- DOI
- https://doi.org/10.3390/ijms21207440
- Journal volume & issue
-
Vol. 21,
no. 20
p. 7440
Abstract
Variations in anxiety-related behavior are associated with individual allostatic set-points in chronically stressed rats. Actively offensive rats with the externalizing indicators of sniffling and climbing the stimulus and material tearing during 10 days of predator scent stress had reduced plasma corticosterone, increased striatal glutamate metabolites, and increased adrenal 11-dehydrocorticosterone content compared to passively defensive rats with the internalizing indicators of freezing and grooming, as well as to controls without any behavioral changes. These findings suggest that rats that display active offensive activity in response to stress develop anxiety associated with decreased allostatic set-points and increased resistance to stress.
Keywords