Nature Communications (Dec 2021)
Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides
- Jinzhu Zhang,
- Minghai Tang,
- Yujie Chen,
- Dan Ke,
- Jie Zhou,
- Xinyu Xu,
- Wenxian Yang,
- Jianxiong He,
- Haohao Dong,
- Yuquan Wei,
- James H. Naismith,
- Yi Lin,
- Xiaofeng Zhu,
- Wei Cheng
Affiliations
- Jinzhu Zhang
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- Minghai Tang
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- Yujie Chen
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- Dan Ke
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- Jie Zhou
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- Xinyu Xu
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- Wenxian Yang
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- Jianxiong He
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- Haohao Dong
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- Yuquan Wei
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- James H. Naismith
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- Yi Lin
- International Peace Maternity and Child Health Hospital, Institute of Embryo-Fetal Original Adult Disease, School of Medicine, Shanghai Jiao Tong University
- Xiaofeng Zhu
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- Wei Cheng
- Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Sichuan University
- DOI
- https://doi.org/10.1038/s41467-021-27144-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Steviol glycosides from the plant Stevia rebaudiana are already used as lowcalorie sweeteners, but the most abundant naturally occurring compounds have a bitter aftertaste. Here, the authors characterize and engineer rice glycosyltransferase OsUGT91C1 to facilitate the large-scale production of naturally rare but palatable glycosides Reb D and Reb M
