Research progress on the role of mucin in the pathogenesis of gastroesophageal reflux disease

Abstract

Gastroesophageal reflux disease （GERD） is a common recurrent disease and the treatment of GERD is challenging. Chronic heartburn and/or reflux symptoms seriously affect the quality of daily life of patients. Studies have shown that GERD is closely associated with the impairment of anti-reflux barrier of the esophagus，of which mucin （MUC） is the main component. The role of MUC in the pathogenesis of GERD and influencing factors were reviewed in this article.

Keywords

• mucin|gastroesophageal reflux|pathogenesis|influencing factor