Frontiers in Cell and Developmental Biology (Mar 2023)
Poly(I:C)-induced maternal immune activation causes elevated self-grooming in male rat offspring: Involvement of abnormal postpartum static nursing in dam
- Xing-Yu Lan,
- Xing-Yu Lan,
- Xing-Yu Lan,
- You-Yu Gu,
- Ming-Juan Li,
- Ming-Juan Li,
- Ming-Juan Li,
- Tian-Jia Song,
- Tian-Jia Song,
- Tian-Jia Song,
- Fu-Jun Zhai,
- Fu-Jun Zhai,
- Fu-Jun Zhai,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Jiang-Shan Zhan,
- Jiang-Shan Zhan,
- Jiang-Shan Zhan,
- Tobias M. Böckers,
- Xiao-Nan Yue,
- Xiao-Nan Yue,
- Xiao-Nan Yue,
- Xiao-Nan Yue,
- Jia-Nan Wang,
- Jia-Nan Wang,
- Jia-Nan Wang,
- Shuo Yuan,
- Shuo Yuan,
- Shuo Yuan,
- Meng-Ying Jin,
- Meng-Ying Jin,
- Meng-Ying Jin,
- Yu-Fei Xie,
- Yu-Fei Xie,
- Yu-Fei Xie,
- Wan-Wen Dang,
- Wan-Wen Dang,
- Wan-Wen Dang,
- Hai-Heng Hong,
- Hai-Heng Hong,
- Hai-Heng Hong,
- Zi-Rui Guo,
- Zi-Rui Guo,
- Zi-Rui Guo,
- Xue-Wei Wang,
- Xue-Wei Wang,
- Xue-Wei Wang,
- Rong Zhang,
- Rong Zhang,
- Rong Zhang,
- Rong Zhang,
- Rong Zhang
Affiliations
- Xing-Yu Lan
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Xing-Yu Lan
- Neuroscience Research Institute, Peking University, Beijing, China
- Xing-Yu Lan
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- You-Yu Gu
- Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China
- Ming-Juan Li
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Ming-Juan Li
- Neuroscience Research Institute, Peking University, Beijing, China
- Ming-Juan Li
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Tian-Jia Song
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Tian-Jia Song
- Neuroscience Research Institute, Peking University, Beijing, China
- Tian-Jia Song
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Fu-Jun Zhai
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Fu-Jun Zhai
- Neuroscience Research Institute, Peking University, Beijing, China
- Fu-Jun Zhai
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Yong Zhang
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Yong Zhang
- Neuroscience Research Institute, Peking University, Beijing, China
- Yong Zhang
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Jiang-Shan Zhan
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Jiang-Shan Zhan
- Neuroscience Research Institute, Peking University, Beijing, China
- Jiang-Shan Zhan
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Tobias M. Böckers
- Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany
- Xiao-Nan Yue
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Xiao-Nan Yue
- Neuroscience Research Institute, Peking University, Beijing, China
- Xiao-Nan Yue
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Xiao-Nan Yue
- Health Bureau of Kenli District, Dongying, China
- Jia-Nan Wang
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Jia-Nan Wang
- Neuroscience Research Institute, Peking University, Beijing, China
- Jia-Nan Wang
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Shuo Yuan
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Shuo Yuan
- Neuroscience Research Institute, Peking University, Beijing, China
- Shuo Yuan
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Meng-Ying Jin
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Meng-Ying Jin
- Neuroscience Research Institute, Peking University, Beijing, China
- Meng-Ying Jin
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Yu-Fei Xie
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Yu-Fei Xie
- Neuroscience Research Institute, Peking University, Beijing, China
- Yu-Fei Xie
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Wan-Wen Dang
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Wan-Wen Dang
- Neuroscience Research Institute, Peking University, Beijing, China
- Wan-Wen Dang
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Hai-Heng Hong
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Hai-Heng Hong
- Neuroscience Research Institute, Peking University, Beijing, China
- Hai-Heng Hong
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Zi-Rui Guo
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Zi-Rui Guo
- Neuroscience Research Institute, Peking University, Beijing, China
- Zi-Rui Guo
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Xue-Wei Wang
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Xue-Wei Wang
- Neuroscience Research Institute, Peking University, Beijing, China
- Xue-Wei Wang
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Rong Zhang
- Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
- Rong Zhang
- Neuroscience Research Institute, Peking University, Beijing, China
- Rong Zhang
- Key Laboratory for Neuroscience, Ministry of Education, National Health and Family Planning Commission, Peking University, Beijing, China
- Rong Zhang
- Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing, China
- Rong Zhang
- Autism Research Center, Peking University Health Science Center, Beijing, China
- DOI
- https://doi.org/10.3389/fcell.2023.1054381
- Journal volume & issue
-
Vol. 11
Abstract
Introduction: Maternal immune activation (MIA) is closely related to the onset of autism-like behaviors in offspring, but the mechanism remains unclear. Maternal behaviors can influence offspring’s development and behaviors, as indicated in both human and animal studies. We hypothesized that abnormal maternal behaviors in MIA dams might be other factors leading to delayed development and abnormal behaviors in offspring.Methods: To verify our hypothesis, we analyzed poly(I:C)-induced MIA dam’s postpartum maternal behavior and serum levels of several hormones related to maternal behavior. Pup’s developmental milestones and early social communication were recorded and evaluated in infancy. Other behavioral tests, including three-chamber test, self-grooming test, open field test, novel object recognition test, rotarod test and maximum grip test, were performed in adolescence of pups.Results: Our results showed that MIA dams exhibit abnormal static nursing behavior but normal basic care and dynamic nursing behavior. The serum levels of testosterone and arginine vasopressin in MIA dams were significantly reduced compared with control dams. The developmental milestones, including pinna detachment, incisor eruption and eye opening, were significantly delayed in MIA offspring compared with control offspring, while the weight and early social communication showed no significant differences between the two groups. Behavioral tests performed in adolescence showed that only male MIA offspring display elevated self-grooming behaviors and reduced maximum grip.Discussion: In conclusion, MIA dams display abnormal postpartum static nursing behavior concomitantly with reduced serum levels of testosterone and arginine vasopressin, possibly involving in the pathogenesis of delayed development and elevated self-grooming in male offspring. These findings hint that improving dam’s postpartum maternal behavior might be a potential regime to counteract delayed development and elevated self-grooming in male MIA offspring.
Keywords
