A general mechanism of ribosome dimerization revealed by single-particle cryo-electron microscopy

Linda E. Franken; Gert T. Oostergetel; Tjaard Pijning; Pranav Puri; Valentina Arkhipova; Egbert J. Boekema; Bert Poolman; Albert Guskov

doi:10.1038/s41467-017-00718-x

Nature Communications (Sep 2017)

A general mechanism of ribosome dimerization revealed by single-particle cryo-electron microscopy

Linda E. Franken,
Gert T. Oostergetel,
Tjaard Pijning,
Pranav Puri,
Valentina Arkhipova,
Egbert J. Boekema,
Bert Poolman,
Albert Guskov

Affiliations

Linda E. Franken: Department of Biophysical Chemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
Gert T. Oostergetel: Department of Biophysical Chemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
Tjaard Pijning: Department of Biophysical Chemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
Pranav Puri: Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
Valentina Arkhipova: Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
Egbert J. Boekema: Department of Biophysical Chemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
Bert Poolman: Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
Albert Guskov: Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen

DOI: https://doi.org/10.1038/s41467-017-00718-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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When bacteria enter the stationary growth phase, protein translation is suppressed via the dimerization of 70S ribosomes into inactive complexes. Here the authors provide a structural basis for how the dual domain hibernation promotion factor promotes ribosome dimerization and hibernation in bacteria.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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