Nature Communications (Feb 2020)

Alterations in promoter interaction landscape and transcriptional network underlying metabolic adaptation to diet

  • Yufeng Qin,
  • Sara A. Grimm,
  • John D. Roberts,
  • Kaliopi Chrysovergis,
  • Paul A. Wade

DOI
https://doi.org/10.1038/s41467-020-14796-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Metabolic adaptation to different diets results in changes to gene expression. Here, the authors characterise the chromatin landscape and transcriptional network in mice on a diet of high saturated fat, compared to a diet high in carbohydrate, finding a dramatic reprogramming of the liver transcriptional network.