Wellcome Open Research (Mar 2022)
Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project [version 2; peer review: 3 approved]
- Arjun Chandna,
- Mavuto Mukaka,
- Tiengkham Pongvongsa,
- Mayfong Mayxay,
- Elizabeth A. Ashley,
- Thomas J. Peto,
- Nan Shwe Nwe Htun,
- Nicholas P.J. Day,
- Tobias Brummaier,
- Marco Liverani,
- Sazid Ibna Zaman,
- Koukeo Phommasone,
- Elizabeth Batty,
- Naomi Waithira,
- Aye Sandar Zaw,
- Ladaporn Bodhidatta,
- Melissa Richard-Greenblatt,
- Watcharintorn Fagnark,
- James J. Callery,
- Sanchai Lertcharoenchoke,
- Shayla Islam,
- Frank Smithuis,
- Janjira Thaipadungpanit,
- Richard J. Maude,
- Arjen M. Dondorp,
- Rupam Tripura,
- Nicholas J. White,
- François Nosten,
- Rusheng Chew,
- Carlo Perrone,
- Meiwen Zhang,
- Jetsumon Sattabongkot,
- Aung Pyae Phyo,
- Aninda Sen,
- Wanlapa Roobsoong,
- Witchayoot Huangsuranun,
- Mohammad Yazid Abdad,
- Salisa Lohavittayavikant,
- Supalert Nedsuwan,
- Vanna Moul,
- Wang Nguitragool,
- Pimsiri Ponsap,
- Yoel Lubell,
- Amit Kumer Neogi,
- William H.K. Schilling,
- Stuart D. Blacksell
Affiliations
- Arjun Chandna
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Mavuto Mukaka
- Action for Health Department, Battambang, Cambodia
- Tiengkham Pongvongsa
- Savannakhet Provincial Health Department, Savannakhet, Lao People's Democratic Republic
- Mayfong Mayxay
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Elizabeth A. Ashley
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Thomas J. Peto
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Nan Shwe Nwe Htun
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- Nicholas P.J. Day
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Tobias Brummaier
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Marco Liverani
- Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK
- Sazid Ibna Zaman
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Koukeo Phommasone
- Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic
- Elizabeth Batty
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Naomi Waithira
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Aye Sandar Zaw
- Myanmar Oxford Clinical Research Unit, Yangon, Myanmar
- Ladaporn Bodhidatta
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- Melissa Richard-Greenblatt
- ORCiD
- University of Pennsylvania, Pennsylvania, USA
- Watcharintorn Fagnark
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- James J. Callery
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Sanchai Lertcharoenchoke
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- Shayla Islam
- Communicable Diseases Programme, BRAC, Dhaka, Bangladesh
- Frank Smithuis
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Janjira Thaipadungpanit
- ORCiD
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- Richard J. Maude
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Arjen M. Dondorp
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Rupam Tripura
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Nicholas J. White
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- François Nosten
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Rusheng Chew
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Carlo Perrone
- ORCiD
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- Meiwen Zhang
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Jetsumon Sattabongkot
- Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- Aung Pyae Phyo
- ORCiD
- Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand
- Aninda Sen
- Communicable Diseases Programme, BRAC, Dhaka, Bangladesh
- Wanlapa Roobsoong
- Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- Witchayoot Huangsuranun
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Mohammad Yazid Abdad
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Salisa Lohavittayavikant
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- Supalert Nedsuwan
- Chiang Rai Provincial Public Health Office, Chiang Rai, China
- Vanna Moul
- Communicable Diseases Programme, BRAC, Dhaka, Bangladesh
- Wang Nguitragool
- ORCiD
- Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- Pimsiri Ponsap
- Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- Yoel Lubell
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Amit Kumer Neogi
- ORCiD
- Communicable Diseases Programme, BRAC, Dhaka, Bangladesh
- William H.K. Schilling
- ORCiD
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Stuart D. Blacksell
- Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
- Journal volume & issue
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Vol. 6
Abstract
In rural areas of South and Southeast Asia malaria is declining but febrile illnesses still account for substantial morbidity and mortality. Village health workers (VHWs) are often the first point of contact with the formal health system, and for patients with febrile illnesses they can provide early diagnosis and treatment of malaria. However, for the majority of febrile patients, VHWs lack the training, support and resources to provide further care. Consequently, treatable bacterial illnesses are missed, antibiotics are overused and poorly targeted, and patient attendance wanes along with declining malaria. This Open Letter announces the start of a new initiative, the Rural Febrile Illness (RFI) project, the first in a series of projects to be implemented as part of the South and Southeast Asian Community-based Trials Network (SEACTN) research programme. This multi-country, multi-site project will run in Bangladesh, Cambodia, Lao PDR, Thailand, and Myanmar. It will define the epidemiological baseline of febrile illness in nine remote and underserved areas of Asia where malaria endemicity is declining and access to health services is limited. The RFI project aims to determine the incidence, causes and outcomes of febrile illness; understand the opportunities, barriers and appetite for adjustment of the role of VHWs to include management of non-malarial febrile illnesses; and establish a network of community healthcare providers and facilities capable of implementing interventions designed to triage, diagnose and treat patients presenting with febrile illnesses within these communities in the future.