Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster

Daniel Wilinski; Jasmine Winzeler; William Duren; Jenna L. Persons; Kristina J. Holme; Johan Mosquera; Morteza Khabiri; Jason M. Kinchen; Peter L. Freddolino; Alla Karnovsky; Monica Dus

doi:10.1038/s41467-019-11933-z

Nature Communications (Sep 2019)

Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster

Daniel Wilinski,
Jasmine Winzeler,
William Duren,
Jenna L. Persons,
Kristina J. Holme,
Johan Mosquera,
Morteza Khabiri,
Jason M. Kinchen,
Peter L. Freddolino,
Alla Karnovsky,
Monica Dus

Affiliations

Daniel Wilinski: Department of Molecular, Cellular and Developmental Biology, The University of Michigan, College of Literature, Science, and the Arts
Jasmine Winzeler: Department of Molecular, Cellular and Developmental Biology, The University of Michigan, College of Literature, Science, and the Arts
William Duren: Department of Computational Medicine and Bioinformatics, The University of Michigan Medical School
Jenna L. Persons: Department of Molecular, Cellular and Developmental Biology, The University of Michigan, College of Literature, Science, and the Arts
Kristina J. Holme: Graduate Program in Molecular & Integrative Physiology, The University of Michigan Medical School
Johan Mosquera: Department of Computational Medicine and Bioinformatics, The University of Michigan Medical School
Morteza Khabiri: Department of Biological Chemistry, The University of Michigan Medical School
Jason M. Kinchen: Metabolon, Inc
Peter L. Freddolino: Department of Computational Medicine and Bioinformatics, The University of Michigan Medical School
Alla Karnovsky: Department of Computational Medicine and Bioinformatics, The University of Michigan Medical School
Monica Dus: Department of Molecular, Cellular and Developmental Biology, The University of Michigan, College of Literature, Science, and the Arts

DOI: https://doi.org/10.1038/s41467-019-11933-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The relationship between metabolomic and behavioral changes is not well understood. Here, the authors analyze metabolome changes in D. melanogaster heads and bodies during hunger and satiety, and develop the Flyscape tool to visualize the resulting metabolic networks and integrate them with other omics data.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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