Nature Communications (May 2022)
Profiling of hMPV F-specific antibodies isolated from human memory B cells
- Xiao Xiao,
- Arthur Fridman,
- Lu Zhang,
- Pavlo Pristatsky,
- Eberhard Durr,
- Michael Minnier,
- Aimin Tang,
- Kara S. Cox,
- Zhiyun Wen,
- Renee Moore,
- Dongrui Tian,
- Jennifer D. Galli,
- Scott Cosmi,
- Michael J. Eddins,
- Nicole L. Sullivan,
- Xiaodong Yan,
- Andrew J. Bett,
- Hua-Poo Su,
- Kalpit A. Vora,
- Zhifeng Chen,
- Lan Zhang
Affiliations
- Xiao Xiao
- Infectious Diseases and Vaccines Discovery, Merck & Co., Inc.
- Arthur Fridman
- Data Science and Scientific Informatics, Merck & Co., Inc.
- Lu Zhang
- Bioinformatics and Biomarker Research, MSD
- Pavlo Pristatsky
- Analytical Research and Development, Merck & Co., Inc.
- Eberhard Durr
- Infectious Diseases and Vaccines Discovery, Merck & Co., Inc.
- Michael Minnier
- AgileOne
- Aimin Tang
- Infectious Diseases and Vaccines Discovery, Merck & Co., Inc.
- Kara S. Cox
- Infectious Diseases and Vaccines Discovery, Merck & Co., Inc.
- Zhiyun Wen
- Infectious Diseases and Vaccines Discovery, Merck & Co., Inc.
- Renee Moore
- Discovery Biologics, Merck & Co., Inc.
- Dongrui Tian
- Wuxi Biortus Biosciences Co. Ltd.
- Jennifer D. Galli
- Infectious Diseases and Vaccines Discovery, Merck & Co., Inc.
- Scott Cosmi
- Eurofins PSS Insourcing Solutions
- Michael J. Eddins
- Computational and Structural Chemistry, Merck & Co., Inc.
- Nicole L. Sullivan
- Infectious Diseases and Vaccines Discovery, Merck & Co., Inc.
- Xiaodong Yan
- Wuxi Biortus Biosciences Co. Ltd.
- Andrew J. Bett
- Infectious Diseases and Vaccines Discovery, Merck & Co., Inc.
- Hua-Poo Su
- Computational and Structural Chemistry, Merck & Co., Inc.
- Kalpit A. Vora
- Infectious Diseases and Vaccines Discovery, Merck & Co., Inc.
- Zhifeng Chen
- Infectious Diseases and Vaccines Discovery, Merck & Co., Inc.
- Lan Zhang
- Infectious Diseases and Vaccines Discovery, Merck & Co., Inc.
- DOI
- https://doi.org/10.1038/s41467-022-30205-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Here, Xiao et al. isolate a large panel of antibodies against human metapneumovirus fusion protein from human B cells, and characterize their epitopes, neutralization activities, and antigen binding specificity, providing a useful framework for understanding the immune response against hMPV.
