Nature Communications (Jul 2021)

Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels

  • M. S. Magalhaes,
  • P. Smith,
  • J. R. Portman,
  • L. H. Jackson-Jones,
  • C. C. Bain,
  • P. Ramachandran,
  • Z. Michalidou,
  • R. H. Stimson,
  • M. R. Dweck,
  • L. Denby,
  • N. C. Henderson,
  • S. J. Jenkins,
  • C. Bénézech

DOI
https://doi.org/10.1038/s41467-021-24684-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

Read online

Diverse macrophage subsets are found in adipose tissue where they regulate its physiology. Here, the authors used single-cell RNA sequencing to analyse the effect of post-prandial lipids on adipose tissue macrophages and identify Tim4 as a regulator of ABCA1+ macrophage function and post-prandial cholesterol transport.