Copper(I)-catalyzed asymmetric 1,6-conjugate allylation

Chang-Yun Shi; Zhi-Zhou Pan; Ping Tian; Liang Yin

doi:10.1038/s41467-020-19293-9

Nature Communications (Oct 2020)

Copper(I)-catalyzed asymmetric 1,6-conjugate allylation

Chang-Yun Shi,
Zhi-Zhou Pan,
Ping Tian,
Liang Yin

Affiliations

Chang-Yun Shi: The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine and China-Thailand Joint Research Institute of Natural Medicine, Shanghai University of Traditional Chinese Medicine
Zhi-Zhou Pan: CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Ping Tian: The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine and China-Thailand Joint Research Institute of Natural Medicine, Shanghai University of Traditional Chinese Medicine
Liang Yin: The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine and China-Thailand Joint Research Institute of Natural Medicine, Shanghai University of Traditional Chinese Medicine

DOI: https://doi.org/10.1038/s41467-020-19293-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Catalytic asymmetric conjugate allylation of unsaturated carbonyl compounds is usually difficult to achieve due to competing 1,2-addition. Here, the authors report a copper(I)-catalyzed asymmetric 1,6-conjugate allylation of 2,2-dimethyl-6-alkenyl-4H-1,3-dioxin-4-ones with good scope and high enantioselectivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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