Case Reports in Nephrology and Dialysis (Jul 2017)

Tolvaptan for the Treatment of Enlarged Polycystic Liver Disease

  • Hiroki Mizuno,
  • Junichi Hoshino,
  • Tatsuya Suwabe,
  • Keiichi Sumida,
  • Akinari Sekine,
  • Yoichi Oshima,
  • Masahiko Oguro,
  • Kyohei Kunizawa,
  • Masahiro Kawada,
  • Rikako Hiramatsu,
  • Noriko Hayami,
  • Eiko Hasegawa,
  • Masayuki Yamanouchi,
  • Naoki Sawa,
  • Kenmei Takaichi,
  • Yoshifumi Ubara

DOI
https://doi.org/10.1159/000477664
Journal volume & issue
Vol. 7, no. 2
pp. 108 – 111

Abstract

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A 44-year-old Japanese woman with autosomal dominant polycystic kidney disease was admitted to our hospital for evaluation of abdominal distension. Her eGFR was 53.7 mL/min/1.73 m2. Total kidney volume was 2,614 mL. Tolvaptan (60 mg/day) was started to treat renal involvement. The patient’s abdominal fullness began to improve and liver volume, indicating advanced polycystic liver disease (PLD), decreased from 9,750 mL to 8,345 mL after 17 months of tolvaptan treatment, though there was no significant change in kidney volume. This case indicates that tolvaptan may be a therapeutic option for hepatomegaly in patients with symptomatic PLD.

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