Nature Communications (Dec 2022)

Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function

  • Liying Zhang,
  • Charlotte Simonsen,
  • Lucie Zimova,
  • Kaituo Wang,
  • Lavanya Moparthi,
  • Rachelle Gaudet,
  • Maria Ekoff,
  • Gunnar Nilsson,
  • Ute A. Hellmich,
  • Viktorie Vlachova,
  • Pontus Gourdon,
  • Peter M. Zygmunt

DOI
https://doi.org/10.1038/s41467-022-35163-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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TRPV2 is activated by temperature and cannabinoids. Here, the authors have used cryo-EM and electrophysiology to identify a cannabinoid binding site distinct from that of cannabidiol as a possible drug target for treatment of inflammation and immune-mediated diseases.