Changes in Ocular Blood Flow After Intravitreal Injection for Diabetic Macular Edema Between Aflibercept and Faricimab

Abstract

Takahiro Mizukami,1 Saya Mizumoto,1 Takuya Ishibashi,1 Satoru Ueno,2 Takayo Toyonishi,1 Kuniko Tachibana,1 Soichiro Mishima,1 Yoshikazu Shimomura1 1Department of Ophthalmology, Fuchu Hospital, Izumi, Osaka, Japan; 2Department of Ophthalmology, PL Byoin, Tondabashi, Osaka, JapanCorrespondence: Takahiro Mizukami, Department of Ophthalmology Fuchu Hospital, Higocho1-10-17, Izumi, Osaka, 594-0076, Japan, Tel [phone], Email [email protected]: In this study, we aimed to evaluate and compare the effects of intravitreal aflibercept (IVA) and intravitreal faricimab (IVF) injections on the blood flow of retinal vessels in the peripapillary region and optic nerve head (ONH) in eyes with diabetic macular edema (DME) using laser speckle flowgraphy (LSFG).Patients and Methods: This study included 20 eyes of 18 patients treated with IVA and 15 eyes of 11 patients treated with IVF for DME. The mean blur rate (MBR) of the ONH and retinal artery and vein of the peripapillary region were measured using LSFG at baseline and 1 month after injection. Central retinal thickness (CRT) and best-corrected visual acuity (BCVA) were measured for all patients.Results: CRT decreased significantly in both IVA-treated (p = 0.0003) and IVF-treated groups (p = 0.0004). Some of the MBR-related parameters of the ONH, such as MBR of all areas (MA), MBR of vascular areas (MV), and MBR of tissue areas (MT), decreased significantly 1 month after IVA and IVF compared to baseline values (MA of IVA, p < 0.0001; MT of IVA, p = 0.0220; MA of IVF, p = 0.0002; MT of IVF, p = 0.0461). MBR of the retinal artery (MBR-A) and vein (MBR-V) also decreased significantly 1 month after IVA and IVF compared with baseline values (MBR-A of IVA, p = 0.0002; MBR-V of IVA, p = 0.0010; MBR-A of IVF, p = 0.0368). No significant difference in ocular perfusion was observed between the IVA-treated and IVF-treated groups.Conclusion: Intravitreal injection led to a reduction in ocular blood flow in both retinal peripapillary vessels and the ONH in both IVA-treated and IVF-treated groups. No significant difference was observed in MBR reduction between the IVA-treated and IVF-treated groups. Our findings warrant further long-term investigations to reveal differences between aflibercept and faricimab.Keywords: diabetic macular edema, diabetic retinopathy, laser speckle flowgraphy, vascular endothelial growth factor, observational study

Keywords

• diabetic macular edema・diabetic retinopathy・laser speckle flowgraphy・vascular endothelial growth factor・observational study