Cyclodextrin Polymers as a Promising Drug Carriers for Stabilization of Meropenem Solutions

Abstract

Here we report the development of new drug carriers for meropenem based on the hydroxypropyl-β-cyclodextrin (HPCD) polymers with variable linkers, namely, 1,6-hexamethylenediisocyanate (HMD), citric acid (CA), succinic anhydride (SA). The structures of obtained polyesters and polyurethanes nanoparticles (120–200 nm) were investigated by NMR and FTIR-spectroscopy. The PXRD pattern demonstrated that HPCD polymers form complexes with meropenem (MP), and the majority of MP molecules are encapsulated into a complex. MP’s imprinting in the HPCD-HMD polymer matrix lead to an encapsulation efficiency of up to 82%. HPCD-HMD and HPCD-SA polymers increase MP’s stability during the storage of its aqueous solution (in 1.4 and 1.2 times, respectively). In contrast, HPCD-CA polymer negatively affects MP’s stability. In prospect, the HPCD-HMD polymer may be promising for the development of a highly efficient drug delivery system for MP.

Keywords

• cyclodextrin polymers
• meropenem
• drug delivery