Nature Communications (Aug 2018)

The identification of carbon dioxide mediated protein post-translational modifications

  • Victoria L. Linthwaite,
  • Joanna M. Janus,
  • Adrian P. Brown,
  • David Wong-Pascua,
  • AnnMarie C. O’Donoghue,
  • Andrew Porter,
  • Achim Treumann,
  • David R. W. Hodgson,
  • Martin J. Cann

DOI
https://doi.org/10.1038/s41467-018-05475-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

Read online

Carbon dioxide can interact with proteins to form carbamate post-translational modifications. Here, the authors developed a strategy to identify carbamate post-translational modifications by trapping carbon dioxide and subsequently identifying the carbamylated proteins.