Nature Communications (Jul 2016)
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia
- Kaiqi Sun,
- Yujin Zhang,
- Angelo D’Alessandro,
- Travis Nemkov,
- Anren Song,
- Hongyu Wu,
- Hong Liu,
- Morayo Adebiyi,
- Aji Huang,
- Yuan E. Wen,
- Mikhail V. Bogdanov,
- Alejandro Vila,
- John O’Brien,
- Rodney E. Kellems,
- William Dowhan,
- Andrew W. Subudhi,
- Sonja Jameson-Van Houten,
- Colleen G. Julian,
- Andrew T. Lovering,
- Martin Safo,
- Kirk C. Hansen,
- Robert C. Roach,
- Yang Xia
Affiliations
- Kaiqi Sun
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Yujin Zhang
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Angelo D’Alessandro
- Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine
- Travis Nemkov
- Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine
- Anren Song
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Hongyu Wu
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Hong Liu
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Morayo Adebiyi
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Aji Huang
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Yuan E. Wen
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Mikhail V. Bogdanov
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Alejandro Vila
- Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston
- John O’Brien
- Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston
- Rodney E. Kellems
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- William Dowhan
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- Andrew W. Subudhi
- Department of Emergency Medicine, Altitude Research Center, University of Colorado School of Medicine
- Sonja Jameson-Van Houten
- Department of Emergency Medicine, Altitude Research Center, University of Colorado School of Medicine
- Colleen G. Julian
- Department of Emergency Medicine, Altitude Research Center, University of Colorado School of Medicine
- Andrew T. Lovering
- Department of Human Physiology, University of Oregon
- Martin Safo
- Department of Medicinal Chemistry, Virginia Commonwealth University
- Kirk C. Hansen
- Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine
- Robert C. Roach
- Department of Emergency Medicine, Altitude Research Center, University of Colorado School of Medicine
- Yang Xia
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston
- DOI
- https://doi.org/10.1038/ncomms12086
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
The presence of the signalling lipid Sphingosine 1-phosphate (S1P) in erythrocytes has unclear physiological implications. Here the authors show that the S1P-generating enzyme Sphingosine kinase type 1 and its product S1P play an important role in the red blood cell adaptation to hypoxic environments in mice and humans.
