Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease

Lesley Cheng; Camelia Quek; Xia Li; Shayne A. Bellingham; Laura J. Ellett; Mitch Shambrook; Saima Zafar; Inga Zerr; Victoria A. Lawson; Andrew F. Hill

doi:10.1038/s42003-021-01868-x

Communications Biology (Mar 2021)

Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease

Lesley Cheng,
Camelia Quek,
Xia Li,
Shayne A. Bellingham,
Laura J. Ellett,
Mitch Shambrook,
Saima Zafar,
Inga Zerr,
Victoria A. Lawson,
Andrew F. Hill

Affiliations

Lesley Cheng: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
Camelia Quek: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne
Xia Li: Department of Mathematics and Statistics, La Trobe University
Shayne A. Bellingham: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne
Laura J. Ellett: Department of Pathology, The University of Melbourne
Mitch Shambrook: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
Saima Zafar: Department of Neurology, University Medical Center Göttingen and German Center for Neurodegenerative Diseases
Inga Zerr: Department of Neurology, University Medical Center Göttingen and German Center for Neurodegenerative Diseases
Victoria A. Lawson: Department of Pathology, The University of Melbourne
Andrew F. Hill: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University

DOI: https://doi.org/10.1038/s42003-021-01868-x
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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Cheng et al. present differentially expressed extracellular vesicle miRNAs in human clinical samples from patients who suffer from sporadic Creutzfeldt-Jakob disease. This study identifies biomarkers that can be used to detect prion-related diseases, providing insights into drug development for inhibiting prion infectivity.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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