Perylenequinones from an endophytic Alternaria sp. of Pinus ponderosa
Mudasir A. Tantry,
Ahmed S. Idris,
John S. Williamson,
Tasfi Shafi,
Jehangir S. Dar,
Tauseef A. Malik,
Bashir A. Ganai,
Abdul S. Shawl
Affiliations
Mudasir A. Tantry
Department of Chemistry, S. P. College, Cluster University Srinagar, Kashmir 190001, India; Phytochemistry Laboratories, Centre of Research for Development, University of Kashmir, Srinagar, Kashmir 190006, India; Corresponding author.
Ahmed S. Idris
Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Benghazi 16063, Libya
John S. Williamson
Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
Tasfi Shafi
Department of Zoology, MLB College, University of Bhopal, Bhopal 462026, India
Jehangir S. Dar
Phytochemistry Laboratories, Centre of Research for Development, University of Kashmir, Srinagar, Kashmir 190006, India
Tauseef A. Malik
Phytochemistry Laboratories, Centre of Research for Development, University of Kashmir, Srinagar, Kashmir 190006, India; Department of Zoology, Government College for Women, Cluster University Srinagar, Kashmir 190001, India
Bashir A. Ganai
Phytochemistry Laboratories, Centre of Research for Development, University of Kashmir, Srinagar, Kashmir 190006, India
Abdul S. Shawl
Natural Products Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Srinagar, Kashmir 190005, India
The differential solvent extraction and further purification of fractions of endophytic Alternaria sp. isolated from Pinus ponderosa led to the isolation of further two perylenequinone compounds as 3,6,6a,9,10-pentahydroxy-7,8-epoxy-4-oxo-4,5,6,6a,6b,7,8,9-octahydroperylene (1) and 3,6,6a,7,10-pentahydroxy-4,9-dioxo-4,5,6,6a,6b,7,8,9-octahydroperylene (2). Structure of compounds 1–2 was determined on the basis of detailed spectroscopic analysis, as well as by comparison with literature reports. The antimicrobial, antileismanial, antimalarial and cytotoxic activities of compound 1 and 2 were evaluated.
