mBio
(Oct 2021)
The Cyclin Cln1 Controls Polyploid Titan Cell Formation following a Stress-Induced G
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Arrest in Cryptococcus
Sophie Altamirano,
Zhongming Li,
Man Shun Fu,
Minna Ding,
Sophie R. Fulton,
J. Marina Yoder,
Vy Tran,
Kirsten Nielsen
Affiliations
Sophie Altamirano
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Zhongming Li
ORCiD Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Man Shun Fu
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Minna Ding
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Sophie R. Fulton
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
J. Marina Yoder
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Vy Tran
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
Kirsten Nielsen
ORCiD Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA
DOI
https://doi.org/10.1128/mBio.02509-21
Journal volume & issue
Vol. 12,
no. 5
Abstract
Read online
Dysregulation of the cell cycle underlies many human genetic diseases and cancers, yet numerous organisms, including microbes, also manipulate the cell cycle to generate both morphologic and genetic diversity as a natural mechanism to enhance their chances for survival. The eukaryotic pathogen Cryptococcus neoformans
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