The influence of ultraviolet irradiation on the antibiotic activity of aranciamycin producer strain Streptomyces echinatus DSM40730

Abstract

The influence of ultraviolet irradiation on spore survival and antibiotic activity of aranciamycin producer strain S. echinatus DSM40730 was investigated. Optimal medium for aranciamycin production and S. echinatus sporulation was selected. Optimal UV dose that leads to 0.7% of S. echinatus spores survival is efficient for screening of aranciamycin overproducers. For determination of the antibiotic activity of S. echinatus strain Sarcina lutea was used.

Keywords

• streptomyces echinatus
• aranciamycin
• ultraviolet irradiation
• anthra­cycline antibiotics