Nature Communications (Aug 2022)
AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1
- George K. E. Umanah,
- Leire Abalde-Atristain,
- Mohammed Repon Khan,
- Jaba Mitra,
- Mohamad Aasif Dar,
- Melissa Chang,
- Kavya Tangella,
- Amy McNamara,
- Samuel Bennett,
- Rong Chen,
- Vasudha Aggarwal,
- Marisol Cortes,
- Paul F. Worley,
- Taekjip Ha,
- Ted M. Dawson,
- Valina L. Dawson
Affiliations
- George K. E. Umanah
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Leire Abalde-Atristain
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Mohammed Repon Khan
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Jaba Mitra
- Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign
- Mohamad Aasif Dar
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Melissa Chang
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Kavya Tangella
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Amy McNamara
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Samuel Bennett
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Rong Chen
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Vasudha Aggarwal
- Department of Biophysics and Biophysical Chemistry, Johns Hopkins University
- Marisol Cortes
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Paul F. Worley
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- Taekjip Ha
- Departments of Biophysics and Biophysical Chemistry, Biophysics and Biomedical Engineering, JHU Howard Hughes Medical Institute
- Ted M. Dawson
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- Valina L. Dawson
- Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-32365-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Signaling via the mTOR complex 1 (mTORC1) maintains cellular and organismal homeostasis. Here the authors show that the AAA + ATPase Thorase binds mTOR to promote disassembly and inactivation of mTORC1 to fine tune TOR signaling according to amino acid availability.
