Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins

Andrea Mascitti; Massimiliano Lupacchini; Ruben Guerra; Ilya Taydakov; Lucia Tonucci; Nicola d’Alessandro; Frederic Lamaty; Jean Martinez; Evelina Colacino

doi:10.3762/bjoc.13.3

Beilstein Journal of Organic Chemistry (Jan 2017)

Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins

Andrea Mascitti,
Massimiliano Lupacchini,
Ruben Guerra,
Ilya Taydakov,
Lucia Tonucci,
Nicola d’Alessandro,
Frederic Lamaty,
Jean Martinez,
Evelina Colacino

Affiliations

Andrea Mascitti: Department of Engineering and Geology (INGEO), G.d’Annunzio University of Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti Scalo, Italy
Massimiliano Lupacchini: Department of Engineering and Geology (INGEO), G.d’Annunzio University of Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti Scalo, Italy
Ruben Guerra: Université de Montpellier, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - UM - ENSCM, Place E. Bataillon, Campus Triolet, 34095 Montpellier CEDEX 5, France
Ilya Taydakov: P.N. Lebedev Institute of Physics of RAS, Leninskiy pr-t, 53, 119991, Moscow, Russia
Lucia Tonucci: Department of Philosophical, Educational and Economic Sciences, G. d’Annunzio University of Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti Scalo, Italy
Nicola d’Alessandro: Department of Engineering and Geology (INGEO), G.d’Annunzio University of Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti Scalo, Italy
Frederic Lamaty: Université de Montpellier, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - UM - ENSCM, Place E. Bataillon, Campus Triolet, 34095 Montpellier CEDEX 5, France
Jean Martinez: Université de Montpellier, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - UM - ENSCM, Place E. Bataillon, Campus Triolet, 34095 Montpellier CEDEX 5, France
Evelina Colacino: Université de Montpellier, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - UM - ENSCM, Place E. Bataillon, Campus Triolet, 34095 Montpellier CEDEX 5, France

DOI: https://doi.org/10.3762/bjoc.13.3
Journal volume & issue: Vol. 13, no. 1
pp. 19 – 25

Abstract

Read online

The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.

Published in Beilstein Journal of Organic Chemistry

ISSN: 1860-5397 (Online)
Publisher: Beilstein-Institut
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.beilstein-journals.org/bjoc

About the journal

Abstract

Keywords