N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase induces transcription via chromatin histone acetylation in fungi

Chang Su; Yang Lu; Haoping Liu

doi:10.1038/ncomms12916

Nature Communications (Oct 2016)

N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase induces transcription via chromatin histone acetylation in fungi

Chang Su,
Yang Lu,
Haoping Liu

Affiliations

Chang Su: Department of Biological Chemistry, University of California
Yang Lu: Department of Biological Chemistry, University of California
Haoping Liu: Department of Biological Chemistry, University of California

DOI: https://doi.org/10.1038/ncomms12916
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Many fungi are able to metabolise environmental N-acetylglucosamine, however the mechanism by which this molecule is sensed is unclear. Su and Lu et al. show that Candida albicansNGS1 fulfils this function by mediating N-acetylglucosamine-dependent histone acetylation at target genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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