The exponentiated-Weibull proportional hazard regression model with application to censored survival data

Abstract

The proportional hazard regression models are widely used statistical tools for analyzing survival data and estimating the effects of covariates on survival times. It is assumed that the effects of the covariates are constant across the time. In this paper, we propose a novel extension of the proportional hazard model by incorporating an exponentiated-Weibull distribution to model the baseline line hazard function. The proposed model offers more flexibility in capturing various shapes of failure rates and accommodates both monotonic and non-monotonic hazard shapes. The performance evaluation of the proposed model and comparison with other commonly used survival models including the generalized log–logistic, Weibull, Gompertz, and exponentiated exponential PH regression models are explored using simulation results. The results demonstrate the ability of the introduced model to capture the baseline hazard shapes and to estimate the effect of covariates on the hazard function accurately. Furthermore, two real survival medical data sets are analyzed to illustrate the practical importance of the proposed model to provide accurate predictions of survival outcomes for individual patients. Finally, the survival data analysis reveal that the model is a powerful tool for analyzing complex survival data.

Keywords

• Survival analysis
• Censored data
• Proportional hazard regression model
• Exponentiated-Weibull distribution
• Maximum likelihood estimation
• Monte Carlo simulation