Infection and Drug Resistance (Aug 2023)
A Case of Invasive Fungal Infection Due to Scedosporium apiospermum in a Patient with Psoriasis
Abstract
Su-Fei Pan,* Shi-Mei Huang,* Lian Xie, Yuan-Yuan Zhang, Yu-Rong Tang, Xiao-Zhen Wang Department of Clinical Laboratory, Shengli Oilfield Central Hospital, Dongying, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Zhen Wang, Department of Clinical Laboratory, Shengli Oilfield Central Hospital, No. 31 Jinan Road, Dongying District, Dongying, Shandong, 257034, People’s Republic of China, Tel +86-18654610519, Email [email protected]: Scedosporium apiospermum (S. apiospermum) is typically reported to be involved in superficial and subcutaneous fungal infections but overlooked in invasive infections, which is associated with a high mortality rate. It poses a diagnostic challenge due to its confusable characteristics to other hyaline hyphomycetes. Here, we reported a psoriasis patient with an invasive S. apiospermum infection. The patient presents an abscess at the intermuscular space of the left hip and an increased C-reactive protein level. Pus culture showed white-greyish, cottonlike colonies with aerial mycelium and terminal oval conidia, suggesting S. apiospermum. This rare fungus was rapidly confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and RNA sequencing. The patient was successfully treated with voriconazole with no recurrence of the abscesses despite delayed treatment. This is the first such case infection report from China that described an unusual case of intermuscular space abscesses due to S. apiospermum. This report highlights the possibility of fungal infections in deeper tissue, as well as the necessity of thorough evaluation and microbiological diagnosis for invasive infections, particularly in immunocompromised patients.Keywords: fungi, fungal infections, infectious diseases, Scedosporium, abscesses, voriconazole
