Oxidative Stress in Non-Obese Women with Polycystic Ovarian Syndrome

Abstract

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases of women. Oxidative stress is an important component of the cardio-metabolic risk seen in these women. Oxidative stress has been reported in obese PCOS women. This study is taken up to study oxidative stress in non-obese PCOS women. Materials and Methods: Twenty five non-obese women with PCOS attending the Endocrinology outpatient Department of Sri Venkateswara Institute of Medical Sciences, Tirupati, India along with 25 healthy BMI matched controls were included in the study. The changes in the lipid peroxidation products (MDA), and total anti oxidant capacity (FRAP) as an index of anti oxidant status along with fasting glucose, insulin and uric acid levels were measured in both groups. Insulin resistance was evaluated by using homeostasis model assessment for insulin resistance [HOMA-IR)= [FPG (mg/dl) × insulin (mIU/L)]/ 405] in both groups. Results: Serum MDA and uric acid levels were increased in the study group compared with controls and FRAP levels were decreased in the study group compared to controls though statistically insignificant. Conclusion: Oxidative stress is also present in non-obese women with PCOS. Oxidative stress further increases the CVD risk in these women.Correcting oxidative stress with antioxidants along with monitoring the antioxidant status using a simple assay like FRAP could have a beneficial effect on oxidative stress induced insulin resistance and hyperandrogenism seen in these women.

Keywords

• cardiovascular risk
• frap
• insulin resistance
• malondialdehyde