Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane

Muriel Masi; Julia Vergalli; Ishan Ghai; Andrea Barba-Bon; Thérèse Schembri; Werner M. Nau; Daniel Lafitte; Mathias Winterhalter; Jean-Marie Pagès

doi:10.1038/s42003-022-04035-y

Communications Biology (Oct 2022)

Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane

Muriel Masi,
Julia Vergalli,
Ishan Ghai,
Andrea Barba-Bon,
Thérèse Schembri,
Werner M. Nau,
Daniel Lafitte,
Mathias Winterhalter,
Jean-Marie Pagès

Affiliations

Muriel Masi: MCT, UMR_MD1, U-1261, Aix-Marseille Université, INSERM, IRBA, Faculté de Pharmacie
Julia Vergalli: MCT, UMR_MD1, U-1261, Aix-Marseille Université, INSERM, IRBA, Faculté de Pharmacie
Ishan Ghai: Department of Life Sciences and Chemistry, Jacobs University Bremen
Andrea Barba-Bon: Department of Life Sciences and Chemistry, Jacobs University Bremen
Thérèse Schembri: MCT, UMR_MD1, U-1261, Aix-Marseille Université, INSERM, IRBA, Faculté de Pharmacie
Werner M. Nau: Department of Life Sciences and Chemistry, Jacobs University Bremen
Daniel Lafitte: MCT, UMR_MD1, U-1261, Aix-Marseille Université, INSERM, IRBA, Faculté de Pharmacie
Mathias Winterhalter: Department of Life Sciences and Chemistry, Jacobs University Bremen
Jean-Marie Pagès: MCT, UMR_MD1, U-1261, Aix-Marseille Université, INSERM, IRBA, Faculté de Pharmacie

DOI: https://doi.org/10.1038/s42003-022-04035-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

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The translocation of cephalosporins across enterobacterial OmpF and OmpC channels is monitored in real-time, demonstrating differential permeation of some cephalosporins through OmpF and OmpC.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal