Brazilian Journal of Medical and Biological Research (Oct 2005)

A conceptual and practical overview of cDNA microarray technology: implications for basic and clinical sciences

  • V. de Mello-Coelho,
  • K.L. Hess

DOI
https://doi.org/10.1590/S0100-879X2005001000011
Journal volume & issue
Vol. 38, no. 10
pp. 1543 – 1552

Abstract

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cDNA microarray is an innovative technology that facilitates the analysis of the expression of thousands of genes simultaneously. The utilization of this methodology, which is rapidly evolving, requires a combination of expertise from the biological, mathematical and statistical sciences. In this review, we attempt to provide an overview of the principles of cDNA microarray technology, the practical concerns of the analytical processing of the data obtained, the correlation of this methodology with other data analysis methods such as immunohistochemistry in tissue microarrays, and the cDNA microarray application in distinct areas of the basic and clinical sciences.

Keywords