Candida auris-associated hospitalizations and outbreaks, China, 2018–2023

Jian Bing; Han Du; Penghao Guo; Tianren Hu; Meng Xiao; Sha Lu; Clarissa J. Nobile; Haiqing Chu; Guanghua Huang

doi:10.1080/22221751.2024.2302843

Emerging Microbes and Infections (Dec 2024)

Candida auris-associated hospitalizations and outbreaks, China, 2018–2023

Jian Bing,
Han Du,
Penghao Guo,
Tianren Hu,
Meng Xiao,
Sha Lu,
Clarissa J. Nobile,
Haiqing Chu,
Guanghua Huang

Affiliations

Jian Bing: Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China
Han Du: Department of Infectious Diseases, Huashan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China
Penghao Guo: Department of Clinical Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
Tianren Hu: Department of Infectious Diseases, Huashan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China
Meng Xiao: Department of Laboratory Medicine, Sate Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
Sha Lu: Department of Dermatology and Venereology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China
Clarissa J. Nobile: Department of Molecular and Cell Biology, University of California, Merced, Merced, USA
Haiqing Chu: Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China
Guanghua Huang: Department of Infectious Diseases, Huashan Hospital, Shanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China

DOI: https://doi.org/10.1080/22221751.2024.2302843
Journal volume & issue: Vol. 13, no. 1

Abstract

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The emerging human fungal pathogen Candida auris has become a serious threat to public health. This pathogen has spread to 10 provinces in China as of December 2023. Here we describe 312 C. auris-associated hospitalizations and 4 outbreaks in healthcare settings in China from 2018 to 2023. Three genetic clades of C. auris have been identified during this period. Molecular epidemiological analyses indicate that C. auris has been introduced and local transmission has occurred in multiple instances in China. Most C. auris isolated from China (98.7%) exhibited resistance to fluconazole, while only a small subset of strains were resistant to amphotericin B (4.2%) and caspofungin (2.2%).

Published in Emerging Microbes and Infections

ISSN: 2222-1751 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Science: Microbiology
Website: https://www.tandfonline.com/journals/temi

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