The pharmacoepidemiology of potential drug-drug interactions in patients with psychiatric disorders

Abstract

Actuality. Drug safety issues in patients with psychiatric disorders are relevant due to specifics of clinical pharmacology of the medicinal products used, possible treatment-resistance of mental illnesses and concomitant use of multiple antipsychotic drugs. One of the aspects of treatment safety is a prediction of drug-drug interactions.The aim of the study was to analyze potential drug-drug interactions in patients with psychiatric disorders.Materials and methods. The study enrolled 500 patients with psychiatric disorders in two age-related groups. Drug therapy was analyzed to reveal potential cases of drug-drug interactions.Results. A total of 1 031 cases of the use of drug combinations leading to drug-drug interactions of various clinical significance were revealed in 72.4 % of patients. There were significant differences between two age-related groups in respect of the specifics of medications use and clinical significance of drug combinations.Conclusion. Prediction of drug-drug interactions is likely to ensure improved drug safety in patients with psychiatric disorders.

Keywords

• межлекарственные взаимодействия
• неблагоприятные лекарственные реакции
• психические заболевания