Molecules (Apr 2014)

Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process

  • Jairo Quiroga,
  • Jaime Gálvez,
  • Rodrigo Abonia,
  • Braulio Insuasty,
  • Alejandro Ortíz,
  • Justo Cobo,
  • Manuel Nogueras

DOI
https://doi.org/10.3390/molecules19044284
Journal volume & issue
Vol. 19, no. 4
pp. 4284 – 4300

Abstract

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Diastereoselective reactions between 4-formylpyrazoles, N-substituted maleimides and glycine derivates led to new series of pyrazolyldipyrrolo [3,4-a:3',4'-f]pyrrolizines and pyrazolylpyrrolo[3,4-c]pyrroles in good yields. The reactions proceeded by a domino process through azomethine ylides formed in situ via a 1,3-dipolar cycloaddition reaction.

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