STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

Siyuan Ding; Jonathan Diep; Ningguo Feng; Lili Ren; Bin Li; Yaw Shin Ooi; Xin Wang; Kevin F. Brulois; Linda L. Yasukawa; Xingnan Li; Calvin J. Kuo; David A. Solomon; Jan E. Carette; Harry B. Greenberg

doi:10.1038/s41467-018-03782-z

Nature Communications (Apr 2018)

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

Siyuan Ding,
Jonathan Diep,
Ningguo Feng,
Lili Ren,
Bin Li,
Yaw Shin Ooi,
Xin Wang,
Kevin F. Brulois,
Linda L. Yasukawa,
Xingnan Li,
Calvin J. Kuo,
David A. Solomon,
Jan E. Carette,
Harry B. Greenberg

Affiliations

Siyuan Ding: Department of Microbiology and Immunology, Stanford University
Jonathan Diep: Department of Microbiology and Immunology, Stanford University
Ningguo Feng: Department of Microbiology and Immunology, Stanford University
Lili Ren: Department of Microbiology and Immunology, Stanford University
Bin Li: Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences
Yaw Shin Ooi: Department of Microbiology and Immunology, Stanford University
Xin Wang: Department of Immunology, Cleveland Clinic
Kevin F. Brulois: Palo Alto Veterans Institute of Research, VA Palo Alto Health Care System
Linda L. Yasukawa: Department of Microbiology and Immunology, Stanford University
Xingnan Li: Department of Medicine, Division of Hematology, Stanford University
Calvin J. Kuo: Department of Medicine, Division of Hematology, Stanford University
David A. Solomon: Department of Pathology, University of California
Jan E. Carette: Department of Microbiology and Immunology, Stanford University
Harry B. Greenberg: Department of Microbiology and Immunology, Stanford University

DOI: https://doi.org/10.1038/s41467-018-03782-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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Cohesin is a multimeric nuclear protein complex which includes STAG2 and is associated with vital roles during cell division. Here in a genome-wide CRISPR-Cas9 screen, the authors identify a novel role of STAG2 as a crucial component of the innate immune response to rotavirus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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