Nature Communications (Jan 2021)
The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization
- Andres Ramirez-Martinez,
- Yichi Zhang,
- Kenian Chen,
- Jiwoong Kim,
- Bercin K. Cenik,
- John R. McAnally,
- Chunyu Cai,
- John M. Shelton,
- Jian Huang,
- Ana Brennan,
- Bret M. Evers,
- Pradeep P. A. Mammen,
- Lin Xu,
- Rhonda Bassel-Duby,
- Ning Liu,
- Eric N. Olson
Affiliations
- Andres Ramirez-Martinez
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- Yichi Zhang
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- Kenian Chen
- Department of Population and Data Sciences, Quantitative Biomedical Research Center University of Texas Southwestern Medical Center
- Jiwoong Kim
- Department of Population and Data Sciences, Quantitative Biomedical Research Center University of Texas Southwestern Medical Center
- Bercin K. Cenik
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- John R. McAnally
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- Chunyu Cai
- Department of Pathology, University of Texas Southwestern Medical Center
- John M. Shelton
- Department of Internal Medicine, University of Texas Southwestern Medical Center
- Jian Huang
- Department of Internal Medicine, University of Texas Southwestern Medical Center
- Ana Brennan
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- Bret M. Evers
- Department of Pathology, University of Texas Southwestern Medical Center
- Pradeep P. A. Mammen
- Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
- Lin Xu
- Department of Population and Data Sciences, Quantitative Biomedical Research Center University of Texas Southwestern Medical Center
- Rhonda Bassel-Duby
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- Ning Liu
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- Eric N. Olson
- Department of Molecular Biology, University of Texas Southwestern Medical Center
- DOI
- https://doi.org/10.1038/s41467-021-20987-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
The nuclear envelope tethers chromatin to the nuclear periphery to control genome architecture. Here, the authors show that Net39 preserves the integrity and gene expression of muscle nuclei in mice, and it may contribute to the pathogenesis of Emery–Dreifuss muscular dystrophy.
