Frontiers in Oncology (Sep 2022)
Understanding the basis of major depressive disorder in oncological patients: Biological links, clinical management, challenges, and lifestyle medicine
- Oscar Fraile-Martinez,
- Oscar Fraile-Martinez,
- Miguel A. Alvarez-Mon,
- Miguel A. Alvarez-Mon,
- Miguel A. Alvarez-Mon,
- Cielo Garcia-Montero,
- Cielo Garcia-Montero,
- Leonel Pekarek,
- Leonel Pekarek,
- Leonel Pekarek,
- Luis G. Guijarro,
- Luis G. Guijarro,
- Guillermo Lahera,
- Guillermo Lahera,
- Guillermo Lahera,
- Miguel A. Saez,
- Miguel A. Saez,
- Miguel A. Saez,
- Jorge Monserrat,
- Jorge Monserrat,
- Domitila Motogo,
- Javier Quintero,
- Javier Quintero,
- Melchor Alvarez-Mon,
- Melchor Alvarez-Mon,
- Melchor Alvarez-Mon,
- Miguel A. Ortega,
- Miguel A. Ortega,
- Miguel A. Ortega
Affiliations
- Oscar Fraile-Martinez
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain
- Oscar Fraile-Martinez
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Miguel A. Alvarez-Mon
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain
- Miguel A. Alvarez-Mon
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Miguel A. Alvarez-Mon
- Department of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, Madrid, Spain
- Cielo Garcia-Montero
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain
- Cielo Garcia-Montero
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Leonel Pekarek
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain
- Leonel Pekarek
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Leonel Pekarek
- Oncology Service, Guadalajara University Hospital, Guadalajara, Spain
- Luis G. Guijarro
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Luis G. Guijarro
- Unit of Biochemistry and Molecular Biology, Department of System Biology, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), University of Alcalá, Alcala de Henares, Spain
- Guillermo Lahera
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain
- Guillermo Lahera
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Guillermo Lahera
- Psychiatry Service, Center for Biomedical Research in the Mental Health Network, University Hospital Príncipe de Asturias Centro de Investigación Biomédica en Red en el Área temática de Salud Mental (CIBERSAM), Alcalá de Henares, Spain
- Miguel A. Saez
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain
- Miguel A. Saez
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Miguel A. Saez
- Pathological Anatomy Service, Central University Hospital of Defence-UAH Madrid, Alcala de Henares, Spain
- Jorge Monserrat
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain
- Jorge Monserrat
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Domitila Motogo
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain
- Javier Quintero
- Department of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor, Madrid, Spain
- Javier Quintero
- Department of Legal Medicine and Psychiatry, Complutense University, Madrid, Spain
- Melchor Alvarez-Mon
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain
- Melchor Alvarez-Mon
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Melchor Alvarez-Mon
- Immune System Diseases-Rheumatology, Oncology Service an Internal Medicine, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), University Hospital Príncipe de Asturias, Alcala de Henares, Spain
- Miguel A. Ortega
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, Spain
- Miguel A. Ortega
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Miguel A. Ortega
- 0Cancer Registry and Pathology Department, Principe de Asturias University Hospital, Alcala de Henares, Spain
- DOI
- https://doi.org/10.3389/fonc.2022.956923
- Journal volume & issue
-
Vol. 12
Abstract
In recent years, the incidence of different types of cancer and patient survival have been rising, as well as their prevalence. The increase in survival in recent years exposes the patients to a set of stressful factors such as more rigorous follow-up and more aggressive therapeutic regimens that, added to the diagnosis of the disease itself, cause an increase in the incidence of depressive disorders. These alterations have important consequences for the patients, reducing their average survival and quality of life, and for these reasons, special emphasis has been placed on developing numerous screening tests and early recognition of depressive symptoms. Despite that cancer and major depressive disorder are complex and heterogeneous entities, they also share many critical pathophysiological mechanisms, aiding to explain this complex relationship from a biological perspective. Moreover, a growing body of evidence is supporting the relevant role of lifestyle habits in the prevention and management of both depression and cancer. Therefore, the present study aims to perform a thorough review of the intricate relationship between depression and cancer, with a special focus on its biological links, clinical management, challenges, and the central role of lifestyle medicine as adjunctive and preventive approaches to improve the quality of life of these patients.
Keywords
- cancer
- depression
- lifestyle medicine
- multidisciplinary approaches
- clinical challenges
- Translational medicine
