New insights into the autophagy-NAD axis in brain disease
Maria Jose Perez,
Michela Deleidi
Affiliations
Maria Jose Perez
German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany; Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
Michela Deleidi
Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; Institut Imagine, INSERM UMR1163 Paris Cité University, 24 boulevard du Montparnasse, 75015 Paris, France; Corresponding author
Sun et al. demonstrate that defects in autophagy cause nicotinamide adenine dinucleotide (NAD) depletion and neurotoxicity.1 Restoring NAD levels rescues cytotoxicity in autophagy-deficient neurons, providing a potential therapy for neurodegenerative and lysosomal storage diseases associated with autophagy defects.
