Frontiers in Endocrinology (Aug 2015)

RXFP1 is targeted by complement C1q Tumor Necrosis Factor-related factor 8 (CTRP8) in brain cancer

  • Thatchawan eThanasupawat,
  • Aleksandra eGlogowska,
  • Maxwell eBurg,
  • William G. Wong,
  • Cuong eHoang-Vu,
  • Sabine eHombach-Klonisch,
  • Thomas eKlonisch

DOI
https://doi.org/10.3389/fendo.2015.00127
Journal volume & issue
Vol. 6

Abstract

Read online

The relaxin-like - RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/ Tumor Necrosis Factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor RXFP1 with functions in brain cancer. Here we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.

Keywords