Nature Communications (Apr 2022)
Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms
- Diana Saleiro,
- Jeremy Q. Wen,
- Ewa M. Kosciuczuk,
- Frank Eckerdt,
- Elspeth M. Beauchamp,
- Chidera V. Oku,
- Gavin T. Blyth,
- Mariafausta Fischietti,
- Liliana Ilut,
- Marco Colamonici,
- William Palivos,
- Paula A. Atsaves,
- Dean Tan,
- Masha Kocherginsky,
- Rona Singer Weinberg,
- Eleanor N. Fish,
- John D. Crispino,
- Ronald Hoffman,
- Leonidas C. Platanias
Affiliations
- Diana Saleiro
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Jeremy Q. Wen
- Division of Hematology-Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University
- Ewa M. Kosciuczuk
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Frank Eckerdt
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Elspeth M. Beauchamp
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Chidera V. Oku
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Gavin T. Blyth
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Mariafausta Fischietti
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Liliana Ilut
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Marco Colamonici
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- William Palivos
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Paula A. Atsaves
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Dean Tan
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Masha Kocherginsky
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Rona Singer Weinberg
- New York Blood Center
- Eleanor N. Fish
- Toronto General Hospital Research Institute, University Health Network & Department of Immunology, University of Toronto
- John D. Crispino
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Ronald Hoffman
- Myeloproliferative Neoplasms Research Consortium
- Leonidas C. Platanias
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- DOI
- https://doi.org/10.1038/s41467-022-29381-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Interferon alpha (IFNalpha) therapy is showing promising results to treat myeloproliferative neoplasms (MPNs). Here, the authors show that IFNalpha response requires ULK1 phosphorylation to induce p38-MAPK signalling but it is counteracted by ROCK1-2 activation suggesting combination therapy of IFNalpha-ROCK1-2 inhibition may improve MPNs treatment.
