Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

Nicholas Mancuso; Simon Gayther; Alexander Gusev; Wei Zheng; Kathryn L. Penney; Zsofia Kote-Jarai; Rosalind Eeles; Matthew Freedman; Christopher Haiman; Bogdan Pasaniuc; The PRACTICAL consortium

doi:10.1038/s41467-018-06302-1

Nature Communications (Oct 2018)

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

Nicholas Mancuso,
Simon Gayther,
Alexander Gusev,
Wei Zheng,
Kathryn L. Penney,
Zsofia Kote-Jarai,
Rosalind Eeles,
Matthew Freedman,
Christopher Haiman,
Bogdan Pasaniuc,
The PRACTICAL consortium

Affiliations

Nicholas Mancuso: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles
Simon Gayther: The Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center
Alexander Gusev: Dana Farber Cancer Institute
Wei Zheng: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Kathryn L. Penney: Department of Epidemiology, Harvard T.H. Chan School of Public Health
Zsofia Kote-Jarai: Division of Genetics and Epidemiology, The Institute of Cancer Research
Rosalind Eeles: Division of Genetics and Epidemiology, The Institute of Cancer Research
Matthew Freedman: Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School
Christopher Haiman: Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Bogdan Pasaniuc: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles
The PRACTICAL consortium

DOI: https://doi.org/10.1038/s41467-018-06302-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Genome-wide association studies (GWAS) have identified hundreds of genomic risk regions for prostate cancer. Here, the authors perform a transcriptome wide association study (TWAS) by incorporating prostate cancer GWAS with gene expression data to identify potential novel prostate cancer risk loci and possible risk mechanisms.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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