Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells

Vincenza Cifarelli; Sila Appak-Baskoy; Vivek S. Peche; Andrew Kluzak; Trevor Shew; Ramkumar Narendran; Kathryn M. Pietka; Marina Cella; Curtis W. Walls; Rafael Czepielewski; Stoyan Ivanov; Gwendalyn J. Randolph; Hellmut G. Augustin; Nada A. Abumrad

doi:10.1038/s41467-021-23808-3

Nature Communications (Jun 2021)

Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells

Vincenza Cifarelli,
Sila Appak-Baskoy,
Vivek S. Peche,
Andrew Kluzak,
Trevor Shew,
Ramkumar Narendran,
Kathryn M. Pietka,
Marina Cella,
Curtis W. Walls,
Rafael Czepielewski,
Stoyan Ivanov,
Gwendalyn J. Randolph,
Hellmut G. Augustin,
Nada A. Abumrad

Affiliations

Vincenza Cifarelli: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Sila Appak-Baskoy: European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University
Vivek S. Peche: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Andrew Kluzak: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Trevor Shew: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Ramkumar Narendran: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Kathryn M. Pietka: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Marina Cella: Department of Pathology and Immunology, Washington University School of Medicine
Curtis W. Walls: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine
Rafael Czepielewski: Department of Pathology and Immunology, Washington University School of Medicine
Stoyan Ivanov: Department of Pathology and Immunology, Washington University School of Medicine
Gwendalyn J. Randolph: Department of Pathology and Immunology, Washington University School of Medicine
Hellmut G. Augustin: European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University
Nada A. Abumrad: Center for Human Nutrition, Department of Medicine, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-021-23808-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Genetic variants in CD36 have been associated with metabolic syndrome. Here, the authors found that lymphatic vessel integrity and lipid transport are influenced by CD36 expression, and lymphatic endothelial cell CD36 deficiency causes visceral obesity and insulin resistance, which are risk factors for metabolic syndrome and diabetes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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