Nature Communications (Nov 2021)

The telomere length landscape of prostate cancer

  • Julie Livingstone,
  • Yu-Jia Shiah,
  • Takafumi N. Yamaguchi,
  • Lawrence E. Heisler,
  • Vincent Huang,
  • Robert Lesurf,
  • Tsumugi Gebo,
  • Benjamin Carlin,
  • Stefan Eng,
  • Erik Drysdale,
  • Jeffrey Green,
  • Theodorus van der Kwast,
  • Robert G. Bristow,
  • Michael Fraser,
  • Paul C. Boutros

DOI
https://doi.org/10.1038/s41467-021-27223-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Despite the known role of telomere length in cancer, its association with genomic features remains unclear. Here, the authors integrate telomere length, genomics, transcriptomics and proteomics in localized prostate cancer and reveal links between telomere maintenance, disease drivers and clinical outcomes.