Plexins function in epithelial repair in both Drosophila and zebrafish

Sa Kan Yoo; Heath G. Pascoe; Telmo Pereira; Shu Kondo; Antonio Jacinto; Xuewu Zhang; Iswar K. Hariharan

doi:10.1038/ncomms12282

Nature Communications (Jul 2016)

Plexins function in epithelial repair in both Drosophila and zebrafish

Sa Kan Yoo,
Heath G. Pascoe,
Telmo Pereira,
Shu Kondo,
Antonio Jacinto,
Xuewu Zhang,
Iswar K. Hariharan

Affiliations

Sa Kan Yoo: Department of Molecular and Cell Biology, University of California
Heath G. Pascoe: Department of Pharmacology, University of Texas Southwestern Medical Center
Telmo Pereira: Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa
Shu Kondo: Genetic Strains Research Center, National Institute of Genetics, 1111 Yata
Antonio Jacinto: CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade NOVA de Lisboa, 130
Xuewu Zhang: Department of Pharmacology, University of Texas Southwestern Medical Center
Iswar K. Hariharan: Department of Molecular and Cell Biology, University of California

DOI: https://doi.org/10.1038/ncomms12282
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Plexins are semaphorin receptors and are well known for their roles in neuronal pathfinding. Here the authors describe a role for Plexin A in healing damaged epithelia in Drosophila and zebrafish. In Drosophila, Plexin A inhibits the GTPase Rap1 to allow epithelial remodelling to facilitate wound repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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