Introduction: Acute eosinophilic appendicitis (AEA) is a rare disease with unknown pathophysiology. Case Report: A 42-years old woman with acute abdominal pain referred to emergency department. Appendicitis confirmed after laboratory tests and sonography. She had a history of allergic reaction 45 days ago while tongue and throat were swollen. In alb test WBC was 7700 with PMN 60%, eosinophils 12% and Lymphocytes 28%. Conclusion: Considering hypersensitivity in physical exam is a suitable way to determine and treatment and preventing of consequent gastro-intestinal complications.
