Somatosensory and transcranial motor evoked potential monitoring in a porcine model for experimental procedures.

PLoS ONE. 2018;13(10):e0205410 DOI 10.1371/journal.pone.0205410


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Journal Title: PLoS ONE

ISSN: 1932-6203 (Online)

Publisher: Public Library of Science (PLoS)

LCC Subject Category: Medicine | Science

Country of publisher: United States

Language of fulltext: English

Full-text formats available: PDF, HTML, XML



Sven Maier
Ulrich Goebel
Sonja Krause
Christoph Benk
Martin A Schick
Hartmut Buerkle
Friedhelm Beyersdorf
Fabian A Kari
Jakob Wollborn


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Time From Submission to Publication: 24 weeks


Abstract | Full Text

Evoked potential monitoring has evolved as an essential tool not only for elaborate neurological diagnostics, but also for general clinical practice. Moreover, it is increasingly used to guide surgical procedures and prognosticate neurological outcome in the critical care unit, e.g. after cardiac arrest. Experimental animal models aim to simulate a human-like scenario to deduct relevant clinical information for patient treatment and to test novel therapeutic opportunities. Porcine models are particularly ideal due to a comparable cardiovascular system and size. However, certain anatomic disparities have to be taken into consideration when evoked potential monitoring is used in animal models. We describe a non-invasive and reproducible set-up useful for different modalities in porcine models. We further illustrate hints to overcome multi-faceted problems commonly occurring while using this sophisticated technique. Our descriptions can be used to answer a plethora of experimental questions, and help to further facilitate experimental therapeutic innovation.