Role of IKKε in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology

Qing-Ao Xiao; Qing-Ao Xiao; Qian He; Qian He; Lun Li; Lun Li; Yinhong Song; Yinhong Song; Yue-ran Chen; Yue-ran Chen; Jun Zeng; Xuan Xia; Xuan Xia

doi:10.3389/fphar.2022.888588

Frontiers in Pharmacology (May 2022)

Role of IKKε in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology

Qing-Ao Xiao,
Qing-Ao Xiao,
Qian He,
Qian He,
Lun Li,
Lun Li,
Yinhong Song,
Yinhong Song,
Yue-ran Chen,
Yue-ran Chen,
Jun Zeng,
Xuan Xia,
Xuan Xia

Affiliations

Qing-Ao Xiao: Department of Endocrinology, The People’s Hospital of China Three Gorges University/the First People’s Hospital of Yichang, Yichang, China
Qing-Ao Xiao: Third-grade Pharmacological Laboratory on Traditional Chinese MedicineState Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, China
Qian He: Department of Endocrinology, The People’s Hospital of China Three Gorges University/the First People’s Hospital of Yichang, Yichang, China
Qian He: National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China
Lun Li: The Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
Lun Li: Department of Microbiology and Immunology, Medical College, China Three Gorges University, Yichang, China
Yinhong Song: The Institute of Infection and Inflammation, China Three Gorges University, Yichang, China
Yinhong Song: Department of Microbiology and Immunology, Medical College, China Three Gorges University, Yichang, China
Yue-ran Chen: Third-grade Pharmacological Laboratory on Traditional Chinese MedicineState Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, China
Yue-ran Chen: Department of Physiology and Pathophysiology, Medical College, China Three Gorges University, Yichang, China
Jun Zeng: Department of Endocrinology, The People’s Hospital of China Three Gorges University/the First People’s Hospital of Yichang, Yichang, China
Xuan Xia: Third-grade Pharmacological Laboratory on Traditional Chinese MedicineState Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, China
Xuan Xia: Department of Physiology and Pathophysiology, Medical College, China Three Gorges University, Yichang, China

DOI: https://doi.org/10.3389/fphar.2022.888588
Journal volume & issue: Vol. 13

Abstract

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IKKε (inhibitor of nuclear factor kappa-B kinase ε) is a member of the noncanonical NF-κB pathway. It participates in the inflammatory response and innate immunity against bacteria. In recent decades, IKKε has been closely associated with metabolic regulation. Inhibition of the IKKε pathway can improve fat deposition in the liver, reduce subcutaneous fat inflammation, and improve liver gluconeogenesis in obesity. IKKε is expected to be a new therapeutic target for metabolic diseases such as nonalcoholic fatty liver disease, diabetes, and obesity. Herein, we summarize the structural characterization, physiological function, and pathological role of IKKε in metabolic diseases and small molecule inhibitors of IKKε.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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